:root{--paper:#f7f4ef;--ink:#262330;--muted:#625e69;--purple:#625078;--line:#ded7e2;--soft:#eeE9f2}
*{box-sizing:border-box}html{scroll-behavior:smooth;scroll-padding-top:100px}body{margin:0;background:var(--paper);color:var(--ink);font:18px/1.75 'Jost',sans-serif}a{color:var(--purple);text-underline-offset:4px}a:hover{color:#3f3153}a:focus-visible,button:focus-visible,[tabindex]:focus-visible{outline:3px solid #8663bd;outline-offset:5px}h1,h2,h3{font-family:'Playfair Display',Georgia,serif;line-height:1.2;letter-spacing:-.025em}h1{font-size:clamp(42px,5.2vw,76px);margin:22px 0}h1 em{font-weight:600;color:var(--purple)}h2{font-size:clamp(29px,3vw,43px);margin:12px 0 26px}h3{font-size:24px;margin:30px 0 15px}p{margin:0 0 22px}.skip{position:absolute;left:20px;top:-100px;background:white;padding:12px;z-index:20}.skip:focus{top:10px}.paper-nav{position:sticky;top:0;z-index:10;background:var(--paper);border-bottom:1px solid var(--line);display:flex;align-items:center;justify-content:space-between;padding:18px max(24px,calc((100vw - 1300px)/2));gap:24px}.paper-nav img{display:block;max-width:100%}.paper-nav nav{display:flex;gap:28px}.paper-nav a{text-decoration:none;font-size:15px}.paper-hero{max-width:1300px;margin:auto;padding:80px 28px 70px;display:grid;grid-template-columns:1.5fr 1fr;gap:65px;align-items:center}.eyebrow{font-size:12px;letter-spacing:.14em;font-weight:600;color:var(--purple);margin-bottom:16px}.standfirst{font-size:23px;line-height:1.55;max-width:660px}.byline{font-size:14px;color:var(--muted)}.actions{display:flex;gap:12px;flex-wrap:wrap;margin-top:28px}.button{display:inline-block;padding:13px 21px;border:1px solid var(--purple);border-radius:5px;background:var(--purple);color:#fff;text-decoration:none;font:500 15px/1.4 'Jost',sans-serif;cursor:pointer}.button:hover{background:#4d3c61;color:white}.secondary{background:transparent;color:var(--purple)}.hero-question{background:#ded5e6;padding:36px;border-radius:6px;transform:rotate(1deg)}.hero-question span{font-size:11px;letter-spacing:.13em;font-weight:700}.hero-question p{font-family:'Playfair Display',Georgia,serif;font-size:29px;line-height:1.45;margin:22px 0}.hero-question small{font-size:12px;color:#5e5369}.paper-layout{max-width:1244px;margin:0 auto 80px;display:grid;grid-template-columns:235px minmax(0,1fr);gap:60px;padding:0 28px}.contents nav{position:sticky;top:120px;padding:25px 0;border-top:1px solid var(--line)}.contents a{display:block;text-decoration:none;font-size:15px;line-height:1.5;padding:8px 0}.paper-body{min-width:0}.paper-body section{padding:45px 0;border-top:1px solid var(--line);scroll-margin-top:110px}.paper-body .ref{font-size:14px;white-space:normal}.callout{border-left:3px solid var(--purple);background:var(--soft);padding:25px 28px;margin:28px 0}.callout>strong{display:block;margin-bottom:12px}.callout p:last-child{margin-bottom:0}.stat-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:16px;margin:30px 0}.stat-grid>div{background:var(--soft);border-radius:4px;padding:22px}.stat-grid strong{font-size:40px;line-height:1.2;color:var(--purple)}.stat-grid p{font-size:16px;line-height:1.55;margin:14px 0}.stat-grid small{font-size:12px;line-height:1.4;display:block;color:var(--muted)}.question-grid{display:grid;gap:18px;margin:30px 0}.question-grid>div{padding:24px;border:1px solid var(--line);border-radius:4px}.question-grid h3{margin:0 0 14px}.question-grid p{margin:0}.steps{padding-left:26px}.steps li{padding:0 0 20px 8px}.table-wrap{overflow-x:auto;margin:25px 0 35px;border:1px solid var(--line);border-radius:4px}.table-hint{font-size:13px;color:var(--muted);margin-bottom:0}table{border-collapse:collapse;min-width:620px;width:100%;font-size:15px;line-height:1.55}caption{text-align:left;padding:15px 20px;background:var(--soft);font-weight:600}th,td{text-align:left;vertical-align:top;padding:17px;border-bottom:1px solid var(--line)}thead th{background:#e6deeb}tbody th{min-width:130px}tr:last-child td,tr:last-child th{border-bottom:none}.timeline>div{padding:24px 0;border-top:1px solid var(--line)}.timeline span{font-size:12px;letter-spacing:.13em;color:var(--purple);font-weight:700}.timeline h3{margin-top:12px}.closing{margin-top:40px;padding:32px;background:var(--soft);border-radius:4px}.closing h3{margin-top:0}.text-link{display:block;margin-top:18px;font-size:15px}.references{font-size:15px;line-height:1.7}.references li{padding:0 0 22px 8px;overflow-wrap:anywhere;scroll-margin-top:100px}.references ol{padding-left:22px}.paper-footer{padding:35px max(28px,calc((100vw - 1188px)/2));background:#e9e2ed;display:flex;align-items:flex-start;gap:35px;justify-content:space-between;font-size:13px}.paper-footer p{margin:0}.paper-footer>a:first-child{font-size:23px;font-weight:700;text-decoration:none}
@media(max-width:1000px){.paper-hero{gap:28px}.paper-layout{grid-template-columns:180px minmax(0,1fr);gap:30px}.hero-question{padding:28px}.hero-question p{font-size:25px}.stat-grid{grid-template-columns:1fr}.stat-grid>div{display:grid;grid-template-columns:100px 1fr;gap:0 20px}.stat-grid p{margin:0}.stat-grid small{grid-column:2}}
@media(max-width:720px){body{font-size:17px}.paper-nav{padding:15px 20px}.paper-nav img{width:100px;height:auto}.paper-nav nav{gap:14px}.paper-nav a{font-size:13px}.paper-hero{grid-template-columns:1fr;padding:45px 22px;gap:25px}.hero-question{transform:none}.standfirst{font-size:20px}.paper-layout{display:block;padding:0 22px}.contents nav{position:static;padding:20px 0;margin-bottom:15px;display:grid;grid-template-columns:1fr 1fr;column-gap:16px}.contents .eyebrow{grid-column:1/-1}.paper-body section{padding:32px 0}.callout,.closing{padding:22px}.paper-footer{flex-direction:column;gap:16px}.actions .button{font-size:14px}.stat-grid>div{padding:18px}}
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}}
@media print{@page{margin:18mm}html{scroll-behavior:auto}body{background:#fff;color:#171717;font:10.5pt/1.55 Georgia,serif}.paper-nav,.contents,.actions,.skip,.table-hint,.closing .button{display:none}.paper-hero{display:block;padding:0 0 20px}.hero-question{transform:none;padding:20px;margin:25px 0;background:#f2eef5}.hero-question p{font-size:18pt}h1{font-size:34pt}h2{font-size:22pt}h3{font-size:15pt}h1,h2,h3{break-after:avoid}.standfirst{font-size:14pt}.paper-layout{display:block;margin:0;padding:0}.paper-body section{padding:20px 0}.table-wrap{overflow:visible}table{min-width:0;font-size:9pt}th,td{padding:9px}thead{display:table-header-group}tr,.callout,.stat-grid>div,.hero-question{break-inside:avoid}.stat-grid{grid-template-columns:repeat(3,1fr)}.stat-grid>div{display:block}.stat-grid strong{font-size:24pt}.stat-grid p{font-size:10pt;margin:10px 0}.references{font-size:9pt}.references a::after{content:' (' attr(href) ')';font-size:8pt;overflow-wrap:anywhere}.paper-footer{background:none;border-top:1px solid #ccc;padding:15px 0;font-size:9pt}.button,.text-link{font-size:10pt}a{color:inherit}.byline{font-size:10pt}}

/* Laboratory use cases */
.use-case{padding:30px 0;border-top:1px solid var(--line);scroll-margin-top:110px}
.use-case:first-child{margin-top:30px}
.use-case h3{font-size:29px;margin:12px 0 22px}
.use-case p:last-child{margin-bottom:0}
.use-case .eyebrow{font-size:11px;line-height:1.6}
@media(max-width:720px){.use-case h3{font-size:25px}.use-case{padding:25px 0}}
@media print{.use-case{padding:18px 0}.use-case h3{font-size:16pt}.use-case .eyebrow{font-size:8pt}}